Treating swelling and fluid retention inpatients with congestive heart failure, cirrhosis, or kidney problems (nephrotic syndrome). It is also used for treatment of high blood pressure. It may also be used to treat or prevent low blood potassium. It may also be used to treat excess secretion of the hormone aldosterone by the adrenal gland.
Spironolactone is a potassium-sparing diuretic. It works by blocking the hormone aldosterone, causing the kidney to eliminate excess water, save potassium, and lower blood pressure.
Do NOT use Spironolactone if:
you are allergic to any ingredient in Spironolactone
you are unable to urinate, have severe kidney problems, or have high blood potassium levels
you are taking a potassium supplement, another potassium-sparing diuretic (eg, amiloride, triamterene), or another aldosterone-blocker (eg, eplerenone)
Contact your doctor or health care provider right away if any of these apply to you.
Before using Spironolactone :
Some medical conditions may interact with Spironolactone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have high acidity in your body fluids; low sodium levels in your blood; liver, heart, or lung disease; diabetes; or high urea or nitrogen in your blood
if you have menstrual disease
Some MEDICINES MAY INTERACT with Spironolactone. Tell your health care provider if you are taking any other medicines, especially any of the following:
Corticosteroids (eg, prednisone) or ACTH because low blood electrolyte levels may occur
Barbiturates (eg, phenobarbital) or narcotics (eg, morphine) because dizziness upon standing may occur
Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin II receptor antagonists (eg, valsartan), cyclosporine, macrolide immunosuppressives (eg, tacrolimus), other potassium sparing diuretics (eg, amiloride, triamterene), other aldosterone-blockers (eg, eplerenone), or potassium
supplements because high blood potassium levels may occur (eg,
listlessness, confusion, abnormal skin sensations of the arms and legs,
heaviness of limbs, slowed heart rate, irregular heart rhythm, potentially
life-threatening slow or irregular heartbeat)
Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because they may decrease Spironolactone 's effectiveness and increase the risk of kidney problems and high blood potassium
Digoxin, digitoxin, lithium, nondepolarizing muscle relaxants (eg, tubocurarine), or quinidine because the risk of their side effects and toxicity may be increased by Spironolactone
Pressor amines (eg, norepinephrine) because their effectiveness may be decreased by Spironolactone
This may not be a complete list of all interactions that may occur. Ask your health care provider if Spironolactone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Spironolactone :
Use Spironolactone as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Spironolactone by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
Spironolactone may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
If you miss a dose of Spironolactone , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, restart the medication and advise your doctor or pharmacist at
your next appointment.
Ask your health care provider any questions you may have about how to use Spironolactone.
Important safety information:
Spironolactone may cause dizziness and drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Spironolactone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Spironolactone can raise your body's potassium levels. This is more likely to occur in people with kidney problems, diabetes, in the elderly, or if the patient is severely ill. Potassium levels must be closely monitored in people with any of these problems or illnesses. If not treated, high potassium levels
can be fatal.
Check with your doctor before you use a salt substitute or a product that has potassium in it.
Lab tests, including kidney function, blood pressure, blood potassium, and chemistries, may be performed while you use Spironolactone. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Spironolactone while you are pregnant. Spironolactone is found in breast milk. Do not breast-feed while taking Spironolactone.
Possible side effects of Spironolactone :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Abdominal cramping; change in sexual ability; clumsiness; confusion; diarrhea; dizziness; drowsiness; headache; frequent urination; nausea; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast tenderness; deepening of voice; dry mouth; enlarged breasts in men; excessive thirst; irregular or lack of menstrual periods; skin rash; slow, irregular, or fast heartbeat; ulcers; unusual muscle weakness; unusual tiredness.
What is the shelf life of the pills?
The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
Disclaimer. Do not treat any information on this site as a recommendation from the doctor. For any questions contact your health care provider.