Buy Cheap Generics

Generics-one.com is a global network of online pharmacies and health professionals that operates in four continents. Generics-one.com is the leader in Generic Prescription Drugs sales.

Trial Packs
$0.00 (0 items)
  Checkout
Categories list Generic Medication InfoMedications by A/ZPharmaceutical News & Reviews


We accept

$1.33$1.61$1.67
Sildenafil citrate 50/100mg
Tadalafil 10/20mg
Vardenafil 20mg



Diabetes: Is There a Cure?

Recent developments in Alberta, Canada, make the hope for a cure a true reality for the 30 million plus diabetics worldwide. In addition, for the estimated 2,200 people a day who are diagnosed with some form of diabetes, it may no longer be an incurable high-risk disease. The picture of all diabetics’ futures may need to be rearranged since successful islet transplantation has been achieved.

This Islet is not a tropical isle but rather one of the 100,000-pancreatic cell clusters called the islets of Langerhans or islets for short, as crossword buffs know. Each islet may include 1,000 to 2,000 beta cells that produce insulin in response to rising blood glucose levels. However, in type 1 diabetics, something kills off those beta cells so they can no longer produce insulin. It is thought that the killer is antibodies from the diabetics’ own immune system that for some unknown reason are on an attack-and-destroy mission with those beta cells in their cross hairs. This is called an autoimmune disease.

Researchers have been trying to transplant islet cells for years but have always run into the same problem. Those lethal antibodies are still present and they still assassinate beta cells, whether they are the manufacturer’s original parts, or on loan from the local donor bank.

The idea of islet transplants is nothing new. They have been futile up until the injection heard round the world. The Juvenile Diabetes Foundation issued a press release, announcing that Researchers at the University of Edmonton in Alberta, Canada, had successfully transplanted islet cells in eight individuals. These diabetics were brittle diabetics who had uncontrollable blood sugars regardless of what they ate or the medication they used. Today, these people are diabetes-symptom-free and have been for almost a year.

The news was overwhelming. The procedure had been tried over 430 times and failed. Now, suddenly, this previously useless procedure offers hope of a cure.

What made the difference between over 430 failures and eight successes was a new immunosuppressive protocol that prevented the assassin antibodies from hitting their mark. According to The New England Journal of Medicine , the key was a glucocorticoid-free immunosuppressive regimen consisting of sirolimus, tacrolimus and daclizumab. In English, that means that doctors had developed a regime of immunosuppressive drugs that had stopped the diabetic’s antibodies from killing the new beta cells. Therefore allowing them to attach and begin to produce insulin in type 1 diabetics whom previously needed to inject insulin to control their blood sugar.

Obviously the eight lucky donor recipients were just a small test to see if the new methods were successful. Now islet transplantation has moved into clinical trials at nine centers through out the world. Those centers are:

JDF Human Islet Distribution Program at the University of Alberta, Edmonton, Canada

JDF Human Islet Distribution Program at JDF Center for Islet Cell Transplantation at Harvard Medical School

JDF Human Islet Distribution Program at the JDF Center for Islet Transplantation at the University of Pennsylvania

JDF Human Islet Distribution Program at the Diabetes Institute of Immunology and Transplantation at the University of Minnesota

JDF Human Islet Distribution Program at the Diabetes Research Training Center of Washington University

JDF Human Islet Distribution Program at the Center for Islet Transplantation in Seattle

JDF Human Islet Distribution Program at the Diabetes Research Institute at the University of Miami

JDF Human Islet Distribution Program at Beta Cell Transplantation at Vrije Universiteit Brusel, Brussels, Belgium

JDF Human Islet Distribution Program at the University of Giessen, Giessen, Germany

Each of these centers will cull through applicants and perform 50-80 trial transplantations to try to duplicate the results of the University of Edmonton and see if this truly is a chance for a diabetes-free life.

Where’s the dotted line to sign on? Not so fast, there are some obstacles that need to be overcome and some more exciting announcements to tickle your toes and fire up your diabetes-free fantasies.

Right now, the transplants are only being done on the most brittle diabetics (those who cannot feel a low blood glucose beginning and find their blood sugars before they even have the chance to perform a glucose test). The reason for the limitations is that these are simply trials or tests. The outcome is not truly known. It is hoped that like the eight at Edmonton, these people will see their diabetes symptoms subside. But as can happen when small-scale success is attempted to be duplicated in large-scale proportions the outcome is unknown. Some of the test subjects could die. Others could find they are actually worse off than before the procedure. On the other hand, it could be found not to work at all on the majority of test subjects. Therefore, those with stable diabetes would be foolish to risk their lives and health on an untested procedure.

Other obstacles may prevent the procedure from wide-scale availability if it is found successful. One of these is the lack of donor pancreases. Aunt Martha cannot decide to donate hers to you because that would make Aunt Martha a diabetic. And cousin Suzy and your dad can’t join her, each donating a portion of their cells because it still puts them at too high a risk for developing the disease themselves. So all donor pancreases must be from fetal tissue or brain-dead organ donors.

What makes the donor shortage even worse is that it takes two donor pancreases for every transplant. So not only is there a shortage of donors, that shortage now becomes doubled.

Since the future of this so-called cure could look dim, why get excited at all? Well, human beings are stubborn. They just do not take no for an answer. In addition, they are crafty and inventive. What is an obstacle today becomes a stepping-stone tomorrow. In fact, there has already been progress in this direction and a whole new possibility of donor cells has come to light.

Researchers at the Joshin Diabetes Center, as reported by the Boston Globe, found gold from normally discarded pancreas tissue from which the islet cells have been removed. Using special culture techniques, they have been able to coax pancreatic ductal cells, which normally secrete very little insulin, to churn out larger amounts of the hormone.

The ductal cells are precursors that give rise to other pancreatic cells. In addition, mature ductal cells make a small amount of insulin, probably as a backup in case of trauma or injury to the pancreas.

Joshin researchers devised a way to turn the clock back in the ductal cells, so that they become immature again and produce more insulin. If the Joshin technique can be made more efficient and routine, this would be an enormous step in starting to address the shortage.

Procedures such as these will continue to be developed and tested until there is a cure available for every diabetic at a reasonable cost.

As of now the procedure is only being performed on type 1 diabetics because they are the most in need of a cure. That isn’t fair, but it is reality. However, there is speculation that this procedure may also benefit type 2 diabetics who still may produce some insulin.

Type 2 diabetes occurs when the body, although it produces insulin, fails to use it in the right way. Their cells do not take up the hormone and therefore fail to convert by-products of carbohydrates and proteins into energy. The cause for this is unknown. It could be because of changes within cell receptors or that the insulin produced is not efficient enough to be used correctly.

It is possible that new beta cells that are more effective will produce better insulin. This will then be accepted more readily by those cell receptors. Insulin that is more efficient might even heal broken down cell receptors.

After the type 1 crisis has passed, there is hope to expand the procedure into type 2s and see if it also may be an effective cure for all types of permanent diabetes.

Recently, University of Florida researchers cured diabetes in mice by transplanting into the rodents insulin-producing stem cells harvested from other mice. Stem cells, found in bone marrow and blood, are parent cells from which all new blood cells developed. Preliminary studies suggest that the technique will work in humans. The next step will be trying the technique with stem cells taken from human cadavers. So if islet transplantation doesn’t pan out, perhaps the mouse cure will.

You can be a part of making the cure a reality. First, stay as healthy a diabetic as you can be. A cure probably would not also remove any complications already in progress, so the healthier you are the better your chances of some day living a diabetes-free life. Follow your treatment plan, diet and have regular doctor follow-ups.

Push your government leaders to release even more money for diabetes research. What once was a dream could very well be a reality in our lifetimes. However, it will take money to grease those wheels. Why not become a supporter and advocate yourself? Get politically involved and don’t expect that others will do all the work. There is always a role for you to play.

Encourage your friends and loved ones to become organ donors. There is a drastic shortage in all needed organs and only by choosing to donate precious organs when you no longer need them can these shortages, including pancreatic ones, be alleviated.

Join your local diabetes associations so that they can remain strong both as powerful Washington lobbyists and as fundraisers for research projects. Moreover, stay informed. The more you know the healthier you will be.

Tags: , ,

Comments are closed.



Disclaimer. Do not treat any information on this site as a recommendation from the doctor. For any questions contact your health care provider.

Buy Pills | Diet Pills | Viagra Overnight US | Cialis Generico | Generic Prescriptions | Herbal drugstore